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Unlocking the Future of Immunization - The Rise of Systems Vaccinology in Modern Vaccine DevelopmentIn the ever-evolving landscape of immunology, the emergence of systems biology has catalyzed a transformative approach to vaccine development, known as systems vaccinology. This interdisciplinary field transcends traditional methodologies by integrating vast amounts of biological data to provide a holistic understanding of how vaccines interact withRead more

Accelerating Vaccine Development with TranscriptomicsThe landscape of vaccine development is undergoing a significant transformation with the advent of transcriptomic approaches. These technologies offer unprecedented insights into the complexities of the immune system, enabling the creation of more effective and targeted vaccines. Understanding Transcriptomics In the cutting-edge field of vaccine development, transcriptomics stands out as a revolutionary approach, offering unprecedented insightsRead more

Injection-Site PainWhich factors influence pain upon subcutaneous injection?Biologics such as vaccines, insulin, monoclonal antibodies, etc., that are now widely developed need to be administered parenterally. While the intravenous (IV) route has historically been the most widely used,  the subcutaneous (SC) route is now accepted and presented as safe and effective, whether in the context of chronic disease or in palliativeRead more

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Immunogenicity SeriesPart 4 - Evaluating and managing immunogenicity for vaccinesImmunogenicity is crucial in vaccine development, it represents the capacity of a substance, such as a vaccine, to elicit an immune response. This reaction can be beneficial, providing protection against diseases, or detrimental, resulting in adverse effects. In vaccine development, the goal is to trigger on-target immunogenicity to activate the immuneRead more

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HypoSkin®, an ex vivo human skin model to predict toxicity & efficacy of subcutaneous drugs Recent advancements in subcutaneous injection testing have brought about significant improvements in drug delivery and patient experience. These advancements include the development of innovative injection devices and formulations that enhance the ease and comfort of subcutaneous drug administration. Market trends also indicate a growing demandRead more

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Understanding Pain & Neurogenic InflammationCan our understanding of pain and neurogenic inflammation help in predicting and managing injection-related pain?Nociception, the neural processes of encoding and processing noxious stimuli, and the sensation of pain are initiated by extreme pressures, temperatures, toxic substances, and inflammatory mediators capable of causing tissue injury. These strong stimuli are recognized by specific nerve cells in theRead more