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Article written by Danny Sullivan and first published in Longevity Technology on October 28th, 2021. The original article is available here. Genoskin can help de-risk antiaging trials with the only live human skin model available for subcutaneous administration testing With its proprietary ex vivo human skin technologies, French partner research organisation Genoskin says it is paving the way to “better,Read more

Top advantages of ordering NativeSkin access® vs sourcing skin directly from hospitals Interested in trying NativeSkin access®? Do you still think that sourcing skin samples directly from hospitals is the only valid way? Let us change your mind with these top advantages to ordering  NativeSkin access® online! NativeSkin access® is a patented human skin model that makes the culture, treatment,Read more

Using NativeSkin® to evaluate poison ivy effects  A couple of months ago, Genoskin’s team started to wonder: “Why not try to better understand poison ivy dermatitis through our NativeSkin® model ?” In this article, we summarize information about what is known regarding the poison ivy reaction and what happens on a macroscopic level when poison ivy toxin is applied toRead more

Human connective tissue mast cells A cellular model to better understand the underlying mechanisms of Injection Site Reactions (ISRs) and other severe allergic reactions. Mast cell culture assays are critical to better understand the kinetics and dynamics underlying inflammatory reactions. Genoskin’s team of experts has developed a method to grow connective tissue-type mast cells (CTMCs) derived from the peripheral bloodRead more

Top things found in human skin (vs in reconstructed human skin models) Skin is our largest organ (2m2). Since the skin is a mandatory test organ for regulatory agencies, every single drug in development needs to be tested for potential skin toxicity. Today, efficacy and safety studies are performed either on animal skin, reconstructed skin, or ex vivo human skin.Read more

Top differences between human and animal skin Are animal models used in skin research? Animal models have been widely used in skin research. They are often used to study percutaneous absorption, wound healing, skin inflammation and psoriasis. These studies require relevant models in terms of structure and immunology to assess human skin response and to de-risk clinical trials on humans. TheRead more